Desloratadin

Desloratadin
Data klinis
Nama dagangClarinex, Deloris, Desdin, Deslotine, Destavell, Simdes, Aerius, Allex, dll[1]
Nama laindeskarboetoksiloratadin[2]
AHFS/Drugs.commonograph
MedlinePlusa602002
License data
Kategori
kehamilan
Rute
pemberian		Oral
Kode ATC
Status hukum
Status hukum
Data farmakokinetika
BioavailabilitasDiserap dengan cepat
Pengikatan protein83 – 87%
MetabolismeUGT2B10, CYP2C8
Metabolit3-Hydroxydesloratadine
Onset aksiwithin 1 hour[6]
Waktu paruh eliminasi27 jam,[6] 33.7 jam pada pasien yang tua[3]
Durasi aksiup to 24 hours[6]
Ekskresi40% sebagai metabolit terkonjugasi dalam urin Jumlah yang sama masuk ke dalam tinja
Pengenal
  • 8-kloro-6,11-dihidro-11-(4-piperdinilidena)- 5H-benzo[5,6]siklohepta[1,2-b]piridin
Nomor CAS
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.166.554 Sunting di Wikidata
Data sifat kimia dan fisik
RumusC19H19ClN2
Massa molar310,83 g·mol−1
Model 3D (JSmol)
  • Clc4cc2c(C(/c1ncccc1CC2)=C3/CCNCC3)cc4
  • InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 checkY
  • Key:JAUOIFJMECXRGI-UHFFFAOYSA-N checkY
  (verify)

Desloratadin adalah trisiklik Antihistamin H1 yang digunakan untuk mengobati alergi. Senyawa kimia ini merupakan metabolit aktif dari loratadin. Nama dagangnya adala Clarinex di Amerika Serikat dan Aerius di Eropa dan Kanada.

Referensi

  1. ^ Murdoch D, Goa KL, Keam SJ (7 April 2003). "Desloratadine: an update of its efficacy in the management of allergic disorders". Drugs. 63 (19): 2051–2077. doi:10.2165/00003495-200363190-00010. PMID 12962522. S2CID 195689362.
  2. ^ Schering Corporation (2000). "CLARITIN brand of Loratadine - Full Prescribing Information (US FDA)" (PDF). US FDA. Diakses tanggal 17 May 2024. loratadine is metabolized to descarboethoxyloratadine predominantly by cytochrome P450 3A4 (CYP3A4) and, to a lesser extent, by cytochrome P450 2D6 (CYP2D6).
  3. ^ a b "Clarinex- desloratadine tablet, film coated". DailyMed. 14 November 2022. Diakses tanggal 18 May 2024.
  4. ^ "Clarinex-D 12 HOUR- desloratadine and pseudoephedrine sulfate tablet, extended release". DailyMed. 14 November 2022. Diakses tanggal 18 May 2024.
  5. ^ "Allex EPAR". European Medicines Agency (EMA). 19 May 2004.
  6. ^ a b c Lieberman P, Hernandez-Trujillo V, Lieberman J, Frew AJ (2008). "Antihistamines". Clinical Immunology. Elsevier. hlm. 1317–1329. doi:10.1016/b978-0-323-04404-2.10089-2. ISBN 9780323044042.


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