ERG3

Sterol C-5 desaturase
Identifiers
OrganismeSaccharomyces cerevisiae
SimbolERG3
Symbols alternatifSC5D, SYR1
Entrez850745
HomoloGene5044
RefSeq (mRNA)NM_001181943
Other data
EC number1.14.19.20
ChromosomeXII: 0.25 - 0.25 Mb

ERG3 atau sterol C-5 desaturase adalah enzim fungi yang berasal dari Saccharomyces cerevisiae. Ortoplog manusia dari ERG3 adalah SC5D.[1] ERG3 terlokalisasi di retikulum endoplasma dan vesikel,[2][3] serta mengatalisis dehidrogenasi C5(6) dari episterol menjadi 5-dehidroepisterol. 5-Dehidroepisterol nantinya akan dikonversi lebih lanjut menjadi ergosterol.[4][5]

Detail struktural tepat dari substrat sterol C-5 desaturase bervariasi di seluruh eukariota. Ditunjukkan di bawah skema reaksi adalah tiga gugus distal yang mungkin beserta jalur biosintetik dan spesies tempat gugus tersebut ditemukan.[6]

Lihat pula

Referensi

  1. ^ Hemmi K, Julmanop C, Hirata D, Tsuchiya E, Takemoto JY, Miyakawa T (March 1995). "The physiological roles of membrane ergosterol as revealed by the phenotypes of syr1/erg3 null mutant of Saccharomyces cerevisiae". Bioscience, Biotechnology, and Biochemistry. 59 (3): 482–6. doi:10.1271/BBB.59.482. PMID 7766188.
  2. ^ Natter K, Leitner P, Faschinger A, Wolinski H, McCraith S, Fields S, Kohlwein SD (May 2005). "The spatial organization of lipid synthesis in the yeast Saccharomyces cerevisiae derived from large scale green fluorescent protein tagging and high resolution microscopy". Molecular & Cellular Proteomics. 4 (5): 662–72. doi:10.1074/mcp.M400123-MCP200. PMID 15716577.
  3. ^ Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD (November 2012). "The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae". Steroids. 77 (13): 1313–20. doi:10.1016/j.steroids.2012.08.015. PMC 3501532. PMID 22982564.
  4. ^ Brumfield KM, Moroney JV, Moore TS, Simms TA, Donze D (January 2010). "Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol". PLOS ONE. 5 (1) e8659. Bibcode:2010PLoSO...5.8659B. doi:10.1371/journal.pone.0008659. PMC 2799552. PMID 20084111.
  5. ^ Miyazaki T, Miyazaki Y, Izumikawa K, Kakeya H, Miyakoshi S, Bennett JE, Kohno S (February 2006). "Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance". Antimicrobial Agents and Chemotherapy. 50 (2): 580–6. doi:10.1128/AAC.50.2.580-586.2006. PMC 1366932. PMID 16436713.
  6. ^ Choe S, Noguchi T, Fujioka S, Takatsuto S, Tissier CP, Gregory BD, et al. (February 1999). "The Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesis". The Plant Cell. 11 (2): 207–21. doi:10.1105/tpc.11.2.207. PMC 144158. PMID 9927639.


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