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Ipilimumab

Ipilimumab ?
Antibodi monoklonal
Type Antibodi utuh
Sumber Manusia
Target CTLA-4
Data klinis
Nama dagang Yervoy
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a611023
Data lisensi US FDA:link
Kat. kehamilan C(US)
Status hukum -only (US)
Rute IV
Pengenal
Nomor CAS 477202-00-9 N
Kode ATC L01XC11
ChemSpider none N
UNII 6T8C155666 YaY
KEGG D04603 YaY
Sinonim BMS-734016,[1] MDX-010,[2] MDX-101
Data kimia
Rumus C6742H9972N1732O2004S40 
Massa mol. 148634.914 g/mol

Ipilimumab (nama dagang Yervoy), adalah antibodi monoklonal yang bekerja untuk mengaktifkan sistem kekebalan tubuh dengan menargetkan CTLA-4, reseptor protein yang menurunkan sistem kekebalan tubuh.

Sel T sitotoksik (CTL) dapat mengenali dan menghancurkan sel-sel kanker. Namun, mekanisme penghambatan mengganggu penghancuran ini. Ipilimumab mematikan mekanisme penghambatan dan memungkinkan CTL berfungsi.[3]

Referensi

  1. ^ "Yervoy, ipilimumab (BMS-734016) - Product Profile - BioCentury". BioCentury Online Intelligence. BioCentury Publications. Diarsipkan dari versi asli tanggal 2016-08-12. Diakses tanggal 11 August 2016. 
  2. ^ USAN. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL - ipilimumab" (Siaran pers). American Medical Association (AMA). Diakses tanggal 2013-01-12.  "Salinan arsip". Diarsipkan dari versi asli tanggal 2016-02-23. Diakses tanggal 2016-11-29. 
  3. ^ Antoni Ribas (28 June 2012). "Tumor immunotherapy directed at PD-1". New England Journal of Medicine. 366 (26): 2517–9. doi:10.1056/nejme1205943. 

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