Nonsteroid
Senyawa nonsteroid adalah golongan obat yang bukan steroid maupun turunan steroid.[1][2] Obat antiinflamasi nonsteroid (OAINS) dibedakan dari kortikosteroid sebagai golongan antiinflamasi.[3]
- Estrogen: benzestrol, bifluranol, estrobin (DBE), dietilstilbestrol (stilbestrol), dienestrol, erteberel, fosfestrol, heksestrol (dihidroksistilbestrol), metalenestril, metestrol, metestrol dipropionat, paroksipropiona, prinaberel, dan trifeniletilena, serta banyak xenoestrogen
- SERM: akolbifen, afimoksifen, arzoksifen, bazedoksifen, broparestrol,klorotrianisena, klomifen, klomifenoksida, siklofenil, droloksifen, enklomifen, endoksifen, etamoksitrifetol, fispemifen, idoksifen, lasofoksifen, levormeloksifen, miproksifen, nafoksidin, nitromifen, ormeloksifen, ospemifen, panomifen, pipendoksifen, raloksifen, tamoksifen, toremifen, trioksifen, zindoksifen, zuklomifen
- Antiandrogen: apalutamida, bikalutamida, simetidin, darolutamida, DIMP, enzalutamida, EPI-001, EPI-506, flutamida, hidroksiflutamida, inokoteron, inokoteron asetat, nilutamida, RU-58642, RU-58841, dan topilutamida
- SARMs: AC-262,356; asetotiolutamida; andarina; BMS-564,929; enobosarm (ostarina); LGD-2226; LGD-3303; LGD-4033; S-23; dan S-40503
- Penghambat aromatase: anastrozol, aminoglutetimida, fadrozol, finrozol, letrozol, liarozol, norendoksifen, rogletimida (piridoglutetimida), vorozol
- Penghambat steroidogenesis lainnya: aminoglutetimida, ketokonazol, orteronel, seviteronel, dll
- Beberapa macam: tanaproget (progestogen), finerenona (antimineralokortikoid), esakserenona (antimineralokortikoid), aparerenona (antimineralokortikoid), AZD5423 (glukokortikoid), maprakorat (SGRM)
Lihat juga
Referensi
- ^ a b Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. hlm. 166–. ISBN 978-1-4612-4096-9.
- ^ a b Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus); Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University (27 July 2005). Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach. Oxford University Press, USA. hlm. 322–. ISBN 978-0-19-802645-7.
- ^ Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". Inflammopharmacology. 22 (5): 263–7. doi:10.1007/s10787-014-0211-2. hdl:10852/45403. PMID 25064056. S2CID 16777111.
Bacaan lanjutan
- Miquel JF, Gilbert J (1988). "A chemical classification of nonsteroidal antagonists of sex-steroid hormone action". J. Steroid Biochem. 31 (4B): 525–44. doi:10.1016/0022-4731(88)90004-0. PMID 3059055.
- Buijsman, Rogier; Hermkens, Pedro; Rijn, Rachel; Stock, H.; Teerhuis, N. (2005). "Non-Steroidal Steroid Receptor Modulators". Current Medicinal Chemistry. 12 (9): 1017–1075. doi:10.2174/0929867053764671. ISSN 0929-8673. PMID 16821162.
- Hermkens PH, Kamp S, Lusher S, Veeneman GH (2006). "Non-steroidal steroid receptor modulators". IDrugs. 9 (7): 488–94. doi:10.2174/0929867053764671. PMID 16821162.
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