Osteosit

Osteosit
Transverse Section Of Bone
Rincian
Pengidentifikasi
Bahasa Latinosteocytus
MeSHD010011
THH2.00.03.7.00003
FMA66779
Daftar istilah anatomi

Osteosit adalah sejenis sel tulang dengan populasi sekitar 10 kali lipat populasi osteoblas dibandingkan dengan jumlah osteoklas yang jauh lebih sedikit daripada jumlah osteoblas.[1][2]

Sepanjang osteogenesis, osteoblas akan melepaskan osteoid disertai peningkatan pencerap inti DAX1 dan enzim GTPase, dan penurunan faktor transkripsi SOX4.[3] sebelum terdiferensiasi menjadi osteosit.[4] Sepanjang proses ini terjadi peningkatan

Osteosit memulai sekresi sklerostin setelah menjadi dewasa di dalam matriks osteoid yang mengalami mineralisasi.[5]

Simtoma hipoksia akan dengan cepat menginduksi kluster diferensiasi osteopontin pada osteosit melalui lintasan protein kinase C, dan memicu osteoklastogenesis yang menghasilkan osteoklas.[6]

Rujukan

  1. ^ (Inggris) "Osteocyte and bone structure". ACTA-Vrije Universiteit, Department of Oral Cell Biology; Klein-Nulend J, Nijweide PJ, Burger EH. Diakses tanggal 2011-07-24.
  2. ^ (Inggris) "Dynamics of the Transition from Osteoblast to Osteocyte". Department of Oral Biology/School of Dentistry, University of Missouri; Sarah L. Dallas dan Lynda F. Bonewald. Diakses tanggal 2011-07-24.
  3. ^ (Inggris) "Transcriptional profiling of human osteoblast differentiation". Women's Health Research Institute, Wyeth Research; Billiard J, Moran RA, Whitley MZ, Chatterjee-Kishore M, Gillis K, Brown EL, Komm BS, Bodine PV. Diakses tanggal 2011-07-24.
  4. ^ (Inggris) "Buried alive: how osteoblasts become osteocytes". Biology Department, Dalhousie University; Franz-Odendaal TA, Hall BK, Witten PE. Diakses tanggal 2011-07-24.
  5. ^ (Inggris) "Matrix Mineralization as a Trigger for Osteocyte Maturation". Division of Anatomy, Department of Oral Growth and Development, Health Sciences University of Hokkaido School of Dentistry, Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences; Kazuharu Irie, Sadakazu Ejiri, Yasunori Sakakura, Toru Shibui, dan Toshihiko Yajima. Diakses tanggal 2011-07-24.
  6. ^ (Inggris) "Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen". Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington; Ted S Gross, Katy A King, Natalia A Rabaia, Pranali Pathare, dan Sundar Srinivasan. Diakses tanggal 2011-07-24.


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