Sekretase

Irisan APP oleh tiga macam enzim sekretase.

Sekretase adalah enzim dari golongan protease, yang berfungsi untuk mengiris protein prekursor amiloid menjadi 3 fragmen, selain fungsi-fungsi yang lain.

Sekretase-beta

  • Sekretase-beta1 (bahasa Inggris: beta-site APP-cleaving enzyme 1, ASP2; memapsin2; BACE; HSPC104; FLJ90568; KIAA1149; BACE1) merupakan enzim dari keluarga peptidase A1 dan protease aspartat berbentuk glikoprotein membran integral tipe 1.[1]
  • Sekretase-beta2 (bahasa Inggris: beta-site APP-cleaving enzyme 2, ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; BACE2) mempunyai kelas yang sama dengan sekretase-beta1, tetapi memiliki berkas genetik pada kromosom 21 dan sering merupakan komplikasi dari sindrom Down.[2]

Rujukan

  1. ^ (Inggris) "BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-30.
  2. ^ (Inggris) "BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-30.

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