Vasokonstriksi

Vasokonstriksi adalah proses penyempitan lumen pembuluh darah akibat kontraksi otot polos.[1] Kontraksi tersebut umumnya disebabkan oleh peningkatan stimulasi saraf simpatis. [2] Vasokonstriksi yang kronis dan berlebihan dapat menyebabkan komplikasi kesehatan seperti hipertensi dan iskemia.[3]
Mekanisme
Mekanisme umum penyebab vasokonstriksi adalah peningkatan konsentrasi kalsium (ion Ca2+) di dalam sel otot polos vaskular.[4] Namun, mekanisme spesifik untuk meningkatkan konsentrasi kalsium intraseluler berbeda-beda tergantung pada jenis vasokonstriktor yang terlibat.
Referensi
- ^ Rosenberg, Leah (2020). Gellman, Marc D. (ed.). Vasoconstriction (dalam bahasa Inggris). Cham: Springer International Publishing. hlm. 2305–2306. doi:10.1007/978-3-030-39903-0_1287. ISBN 978-3-030-39903-0.
- ^ Gerard J., Tortora (2017). Principles of Anatomy and Physiology 15th Edition. John Wiley & Sons. hlm. 772. ISBN 978-1-119-32064-7. Pemeliharaan CS1: Status URL (link)
- ^ Khan, Maqsood; Bordes, Stephen J.; Murray, Ian V.; Sharma, Sandeep (2024). Physiology, Pulmonary Vasoconstriction. Treasure Island (FL): StatPearls Publishing. PMID 29763137.
- ^ Wilson, David P.; Susnjar, Marija; Kiss, Enikő; Sutherland, Cindy; Walsh, Michael P. (2005-08-01). "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697". Biochemical Journal (dalam bahasa Inggris). 389 (3): 763–774. doi:10.1042/BJ20050237. ISSN 0264-6021. PMC 1180727. PMID 15823093. ; Pemeliharaan CS1: Format PMC (link)
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