Crime boss Jacob Calder is about to be sent to prison as a result of testimony by federal agent Michael Cates. Calder has Cates's wife and daughter killed and tries to have Cates himself finished off as well. In order to foil Calder's hitmen, Cates's boss, Burton Hardesty, convinces him to adopt the created identity of Chance Bowman, the driver of a Kenworth T2000 semi-truck. Bowman takes to the road, supported remotely by Agent Celia Baxter and Hardesty. In his travels, Bowman encounters various people and often helps them with their problems (not unlike the protagonists of The Incredible Hulk and The Fugitive).