The previous year's event had been a huge disappointment, with the poorly-attended games played in the Orange Bowl, a stadium wholly unsuited for baseball. But Series organizers placed the 1991 event in Miami again, this time at the much-better-suited Bobby Maduro Stadium, an actual ballpark. Attendance improved, with 7,742 at the final game in the 11,500-capacity stadium;. This was the last Caribbean Series to be held in American soil until 2024 at the same city.
Unlike previous years, the four teams played a six-game round robin schedule, each team facing the other teams once, followed by a three-game playoff round and a best-of-three series. (The playing format, called Winterball I, was not used again in the Series.)
This time, the Tigres del Licey became the first Dominican Republic club to clinch two Caribbean Series titles with an undefeated record. The Tigres had won its first title in 1971 edition. As a result, Licey is the only team with an undefeated record in three editions of the Series.
Licey, with John Roseboro at the helm, won the Series behind a strong offensive outburst and fine pitching performance, outscoring its rivals 50–8 to set a Series record. In the first round, the Dominican team defeated Puerto Rico 8–2, blanked Mexico 4–0, and crushed Venezuela 12–1. Then, they extended their overwhelming dominance over Venezuela in the final round with scores of 13–4 and 13–1.