The 2007 CAF Confederation Cup was the fourth edition of the CAF Confederation Cup. Its schedule began with the preliminary round (home-and-away ties) in late January and mid-February with the second round in March and the third round in April.
1Benfica de Luanda were ejected from the competition for fielding an ineligible player.
Play-off round
The 8 winners of the round of 16 play the losers of the round of 16 of the Champions League for 8 places in the group stage.
1st legs played 4–6 May 2007 and 2nd legs played 18–20 May 2007.