Attendance: 15,411 Referee: Grant Atkins, Chris Sutton Player of the Match: Bryce Cartwright
* 14 May - Manly home game despite playing Brisbane Broncos in Brisbane. Match played as part of an NRL double header at Suncorp Stadium. * 16 July - Manly home game played in Perth.
Player statistics
Note: Games and (sub) show total games played, e.g. 1 (1) is 2 games played.
On 27 April, Manly team captain Jamie Lyon announced that he would retire from playing at the end of the 2016 NRL season after 17 seasons of first grade and representative football in both the NRL and the Super League.[29]
Tim Moltzen retired from playing effective immediately on 6 May 2016 due to chronic knee injuries. He was replaced in the squad by Matthew Wright who was signed mid-season after being granted a release from the North Queensland Cowboys.[30]
On 23 June the Manly-Warringah Sea Eagles released Luke Burgess and Feleti Mateo from their contracts. Both players had signed with Super League team the Salford Red Devils the previous day.[32]