Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: Soccerway Rules for classification: 1) Points; 2) Head-to-Head points; 3) Head-to-Head goal difference; 4) Head-to-Head goals scored; 5) Head-to-Head away goals scored; 6) Goal difference; 7) Goals scored. (Note: Head-to-head record is used only after all the matches between the teams in question have been played). (C) Champions Notes:
Al Ahly entered the competition for the 3rd consecutive time after winning the league and the CAF Champions League in the previous season. Al Ahly were ranked first in the CAF 5-year ranking prior to the start of the 2020–21 season. As a result, they entered the competition from the first round.
^The Al Ahly v Al Nasr match, originally scheduled to be played on 19 February 2021, was postponed to avoid scheduling conflicts with Al Ahly's Champions League fixtures.[24] The match was later rescheduled to be played on 14 April 2021.
^The Al Ahly v Al Merrikh match, originally scheduled to be played on 13 February 2021, was rescheduled to be played on 16 February 2021 due to Al Ahly's participation in the 2020 FIFA Club World Cup in Qatar between 4 and 11 February 2021.[25]