The 2020–21 Spezia Calcio season was the club's 115th season in existence and the club's first season in the top flight of Italian football. In addition to the domestic league, Spezia participated in this season's edition of the Coppa Italia. The season covered the period from 3 August 2020 to 30 June 2021.
Source: Serie A, Soccerway Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Draw. (Note: Head-to-head record is used only after all the matches between the teams in question have been played)[2]
Note: Match awarded 3–0 to Spezia, due to Roma making six substitutions instead of the maximum five allowed. Spezia had originally won 4–2 after extra time.[5]