The 2021–22 Derde Divisie season was the sixth edition of the Dutch fourth tier, formerly called Topklasse, since the restructuring of the league system in the summer of 2016.
Source: Soccerway[1] Rules for classification: Season in progress: 1) Most points won; 2) Less points lost; 3) Goal difference; 4) Goals scored; 5) Alphabetical order; End of season: 1) Points; 2) Goal difference; 3) Goals scored; 4) Head-to-head points; 5) Head-to-head goal difference; 6) Head-to-head away goals scored; 7) Play-off if relevant for deciding champion, relegation or participating in a European league, otherwise by draw. 8) Penalty shoot-out (only after a play-off)[2] (C) Champions; (O) Play-off winners; (P) Promoted; (R) Relegated Notes:
Source: Soccerway[5] Rules for classification: Season in progress: 1) Most points won; 2) Less points lost; 3) Goal difference; 4) Goals scored; 5) Alphabetical order; End of season: 1) Points; 2) Goal difference; 3) Goals scored; 4) Head-to-head points; 5) Head-to-head goal difference; 6) Head-to-head away goals scored; 7) Play-off if relevant for deciding champion, relegation or participating in a European league, otherwise by draw. 8) Penalty shoot-out (only after a play-off)[2] (C) Champions; (P) Promoted; (R) Relegated Notes:
Source: Soccerway[6] Legend: Blue = home team win; Yellow = draw; Red = away team win.
Promotion/relegation play-offs
Derde Divisie promotion/relegation playoffs
Since Kozakken Boys and GVVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Derde Divisie for one spot in the 2022–23 Tweede Divisie.[7]
Since ODIN '59 and VVOG finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Hoofdklasse Saturday for two spots in the 2022–23 Derde Divisie.
Since Hoogland and EVV finished 16th and 17th respectively, they will have to play relegation playoffs against teams from the Hoofdklasse Sunday for two spots in the 2022–23 Derde Divisie.