A total of 8 teams are competing in the league. These include 7 teams from the 2020–21 season and one promoted team from the "A" Division: Bălți.
Changes
Bălți (promoted after a two-year absence) were promoted from the "A" Division. Dacia Buiucani (relegated after one year in the top flight) and Codru Lozova (relegated after two years in the top flight) were relegated to "A" Division. Additionally, Speranța Nisporeni were expelled from the league, and thus ending their six-year stay in the top flight.
Source: FMF, UEFA, Soccerway Rules for classification: 1) Points; 2) Play-off (only if deciding champion when two teams tied); 3) Head-to-head points; 4) Head-to-head goal difference; 5) Head-to-head away goals scored; 6) Head-to-head goals scored; 7) Matches won; 8) Goal difference; 9) Goals scored; 10) Least red cards; 11) Least yellow cards.[12] (C) Champions; (O) Play-off winners; (R) Relegated Notes:
^Florești had 6 points deducted for alleged match-fixing.[9]
^On 17 January 2022, Florești were excluded from competition for match-fixing allegations and relegated to the second tier league for next season. All remaining 9 matches were awarded 0–3 against them.[10][11]
Results
Teams played each other four times (twice at home, twice away).
A play-off match was played between the seventh-placed team from Divizia Națională and the fourth-placed team from Divizia A for one place in the next season. The "home" team (for administrative purposes) was determined in a draw held on 19 May 2022.[14]