The 2021—22 Ligue 1 was a season of top-flight football in Senegal.
Casa Sports won the title for the second time and first since 2012 after drawing 1–1 against Tengueth FC on the second-to-last match day.[1][2] The champions also won the double, defeating l'Etoile Lusitana 3–0 in the cup final to go with their league championship.[3]
ASEC Ndiambour were relegated on the final day of the season after losing to AS Pikine after keeping their hopes alive with a win in the penultimate matchday. Ndiambour departed Ligue 1 after a four-season stay.[4] Mbour Petite Côte were confirmed relegated after a 2–1 defeat to CNEPS Thiès in round 24, exiting the top flight for the first time since 2012.[5]