The 2021–22 season was the 73rd season in the existence of UD Las Palmas and the club's fourth consecutive season in the second division of Spanish football. In addition to the domestic league, Las Palmas participated in this season's edition of the Copa del Rey.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.