First round: 28 teams (ranked 27–54) played home-and-away over two legs. The 14 winners advanced to the second round.
Second round: 40 teams (ranked 1–26 and 14 first round winners) were divided into ten groups of four teams to play home-and-away round-robin matches. The ten group winners advanced to the third round.
Third round: Ten second round group winners played home-and-away over two legs. The five winners qualified for the World Cup.
Entrants
All 54 FIFA-affiliated football associations from CAF entered qualification. The FIFA World Rankings of July 2019 were used to determine which nations would compete in the first round. For seeding in the second and third round draws, the most recent FIFA Rankings prior to those draws were used.
Libya was threatened with exclusion from the qualifiers if it failed to pay debts to their former coach Javier Clemente. However, Libya complied after FIFA gave them a new deadline.[4]Sierra Leone also faced possible exclusion from the qualifiers due to the suspension of their football association.[5] However, the suspension was lifted by the FIFA Council on 3 June 2019.[6]
Below is the schedule of the 2022 FIFA World Cup qualifying campaign, according to the FIFA International Match Calendar.[8][9] After the rescheduling of the 2021 Africa Cup of Nations final tournament from June/July to January/February, the dates of the matchdays 1–2 of the second round were also rescheduled.[10] Because of the interruption of the competition due to the COVID-19 pandemic, the schedule of the second and third round was revised again and on 19 August 2020 CAF announced the new dates for the aforementioned rounds.[11]
The ten group winners from the second round were drawn into five home-and-away ties, with the teams seeded based on FIFA World Rankings. The draw was held on 22 January 2022 in Douala, Cameroon.[15] The lower ranked team played the first leg at home. The winners of each fixture qualified for the 2022 FIFA World Cup.