4-hydroxyproline epimerase

In enzymology, a 4-hydroxyproline epimerase (EC 5.1.1.8) is an enzyme that catalyzes the chemical reaction

trans-4-hydroxy-L-proline ${\displaystyle \rightleftharpoons }$ cis-4-hydroxy-D-proline

Hence, this enzyme has one substrate, trans-4-hydroxy-L-proline, and one product, cis-4-hydroxy-D-proline.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase. Other names in common use include hydroxyproline epimerase, hydroxyproline 2-epimerase, and L-hydroxyproline epimerase. This enzyme participates in arginine and proline metabolism.

• Adams E, Norton IL (May 1964). "Purification and properties of inducible hydroxyproline 2-epimerase from Pseudomonas". The Journal of Biological Chemistry. 239: 1525–35. PMID 14189888.