ABCG1

ABCG1
Identifiers
Aliases	ABCG1, ABC8, WHITE1, ATP binding cassette subfamily G member 1
External IDs	OMIM: 603076; MGI: 107704; HomoloGene: 21022; GeneCards: ABCG1; OMA:ABCG1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 42,199,689 bp[1] End 42,297,244 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 31,276,649 bp[2] End 31,336,962 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland right adrenal cortex jejunal mucosa left adrenal cortex spleen Skeletal muscle tissue of rectus abdominis lower lobe of lung amniotic fluid internal globus pallidus Top expressed in globus pallidus right lung lobe olfactory tubercle stria vascularis dorsal striatum medial dorsal nucleus median eminence arcuate nucleus olfactory epithelium lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein dimerization activity protein homodimerization activity ADP binding phospholipid transporter activity ABC-type sterol transporter activity cholesterol binding ATPase activity toxin transmembrane transporter activity protein binding protein heterodimerization activity phospholipid binding ATP binding cholesterol transfer activity ATPase-coupled transmembrane transporter activity Cellular component integral component of membrane recycling endosome endosome Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane plasma membrane integral component of plasma membrane endoplasmic reticulum mitochondrion external side of plasma membrane Biological process phospholipid homeostasis lipid transport regulation of transcription, DNA-templated detection of hormone stimulus phospholipid efflux glycoprotein transport cholesterol transport cholesterol metabolic process response to organic substance negative regulation of cholesterol storage response to lipid intracellular cholesterol transport low-density lipoprotein particle remodeling positive regulation of cholesterol efflux transmembrane transport cholesterol efflux positive regulation of cholesterol biosynthetic process negative regulation of lipid storage cholesterol homeostasis regulation of cholesterol esterification negative regulation of macrophage derived foam cell differentiation amyloid precursor protein catabolic process reverse cholesterol transport toxin transport high-density lipoprotein particle remodeling transport cellular response to high density lipoprotein particle stimulus positive regulation of protein secretion positive regulation of amyloid-beta formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9619 11307 Ensembl ENSG00000160179 ENSMUSG00000024030 UniProt P45844 Q64343 RefSeq (mRNA) NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629 NM_207630 NM_009593 RefSeq (protein) NP_004906 NP_058198 NP_997057 NP_997510 NP_997511 NP_997512 NP_033723 Location (UCSC) Chr 21: 42.2 – 42.3 Mb Chr 17: 31.28 – 31.34 Mb PubMed search [3] [4]
Wikidata
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ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene.^[5][6][7] It is a homolog of the well-known Drosophila gene white.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily (subfamily G). It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.^[7]

• ATP-binding cassette transporter

• ABCG1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCG1 genome location and ABCG1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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