ADAM22

ADAM22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3G5C
Identifiers
Aliases	ADAM22, ADAM 22, MDC2, ADAM metallopeptidase domain 22, EIEE61, DEE61
External IDs	OMIM: 603709; MGI: 1340046; HomoloGene: 37898; GeneCards: ADAM22; OMA:ADAM22 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	88,202,889 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	8,418,160 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; middle temporal gyrus; ; pons; ; Brodmann area 23; ; postcentral gyrus; ; orbitofrontal cortex; ; Brodmann area 46; ; cerebellum; ; cerebellar hemisphere; ; superior frontal gyrus;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; dorsal striatum; ; lateral septal nucleus; ; subiculum; ; anterior amygdaloid area; ; medial geniculate nucleus; ; nucleus accumbens; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	integrin binding; metalloendopeptidase activity; protein binding; metallopeptidase activity;
Cellular component	integral component of membrane; axon; plasma membrane; cell projection; membrane; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	Schwann cell differentiation; adult locomotory behavior; negative regulation of cell adhesion; central nervous system development; cell adhesion; myelination in peripheral nervous system; proteolysis; gliogenesis;
	Sources:Amigo / QuickGO
Orthologs
	53616
	11496
	ENSG00000008277
	ENSMUSG00000040537
	Q9P0K1
	Q9R1V6
NM_004194; NM_016351; NM_021721; NM_021722; NM_021723;
	NM_001324417; NM_001324418; NM_001324419; NM_001324420; NM_001324421; NM_001391975; NM_001391976; NM_001391977; NM_001391978; NM_001391979; NM_001391980; NM_001391981; NM_001391982
	NM_001007220; NM_001007221; NM_001098225; NM_001310439; NM_001310440
NP_001311346; NP_001311347; NP_001311348; NP_001311349; NP_001311350;
	NP_004185; NP_057435; NP_068367; NP_068368; NP_068369
	NP_001007221; NP_001007222; NP_001091695; NP_001297368; NP_001297369
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 22, also known as ADAM22, is an enzyme that in humans is encoded by the ADAM22 gene.^[5]^[6]^[7]

Function

ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. Alternative splicing results in several transcript variants.^[7]

Interactions

ADAM22 has been shown to interact with DLG4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000008277 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040537 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (August 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
^ Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (September 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
^ ^a ^b "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".
^ Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (September 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.

External links

The MEROPS online database for peptidases and their inhibitors: M12.978
Human ADAM22 genome location and ADAM22 gene details page in the UCSC Genome Browser.