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ADGRL4
Identifiers
Aliases	ADGRL4, ETL, KPG_003, ELTD1, adhesion G protein-coupled receptor L4
External IDs	OMIM: 616419; MGI: 2655562; GeneCards: ADGRL4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	79,282,124 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	151,250,723 bp
RNA expression pattern
	Top expressed in
	pericardium; ; visceral pleura; ; parietal pleura; ; subcutaneous adipose tissue; ; Achilles tendon; ; smooth muscle tissue; ; lower lobe of lung; ; gallbladder; ; vena cava; ; mammary gland;
	Top expressed in
	right lung; ; zygote; ; interventricular septum; ; right lung lobe; ; myocardium of ventricle; ; soleus muscle; ; brown adipose tissue; ; right ventricle; ; endothelial cell of lymphatic vessel; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; protein dimerization activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; cytoplasmic vesicle; membrane; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64123
	170757
	ENSG00000162618
	ENSMUSG00000039167
	Q9HBW9
	Q923X1
	NM_022159
	NM_133222
	NP_071442
	NP_573485
	Wikidata
View/Edit Human	View/Edit Mouse

Adhesion G protein-coupled receptor L4 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ADGRL4 gene.^[5]^[6] ADGRL4 appears to have a role in angiogenesis,^[7] both physiological and pathological in cancer.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039167 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nechiporuk T, Urness LD, Keating MT (February 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". The Journal of Biological Chemistry. 276 (6): 4150–7. doi:10.1074/jbc.M004814200. PMID 11050079.
^ "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".
^ Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, et al. (August 2013). "A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637.
^ Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy. 8: 3767–74. doi:10.2147/OTT.S93843. PMC 4689259. PMID 26719704.

Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039167 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050079-5] Nechiporuk T, Urness LD, Keating MT (February 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". The Journal of Biological Chemistry. 276 (6): 4150–7. doi:10.1074/jbc.M004814200. PMID 11050079.

[entrez-6] "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".

[pmid23871637-7] Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, et al. (August 2013). "A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637.

[8] Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy. 8: 3767–74. doi:10.2147/OTT.S93843. PMC 4689259. PMID 26719704.

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ADGRL4

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