APBA3

APBA3
Identifiers
AliasesAPBA3, MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3
External IDsOMIM: 604262; MGI: 1888527; GeneCards: APBA3
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9546

57267

Ensembl

ENSG00000011132

ENSMUSG00000004931

UniProt

O96018

O88888

RefSeq (mRNA)

NM_004886

NM_018758

RefSeq (protein)

NP_004877

NP_061228

Location (UCSC)Chr 19: 3.75 – 3.76 MbChr 10: 81.1 – 81.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amyloid beta A4 precursor protein-binding family A member 3 is a protein that in humans is encoded by the APBA3 gene.[5][6]

Function

The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.[6]

Interactions

APBA3 has been shown to interact with Amyloid precursor protein.[5][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011132 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004931 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Tanahashi H, Tabira T (Apr 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem Biophys Res Commun. 255 (3): 663–7. Bibcode:1999BBRC..255..663T. doi:10.1006/bbrc.1999.0265. PMID 10049767.
  6. ^ a b "Entrez Gene: APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2)".
  7. ^ Biederer T, Cao X, Südhof TC, Liu X (Sep 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. 22 (17): 7340–51. doi:10.1523/JNEUROSCI.22-17-07340.2002. PMC 6757996. PMID 12196555.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Amyloid-beta A4 precursor protein-binding family A member 3 (APBA3)
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