APOBEC3D

APOBEC3D
Identifiers
AliasesAPOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, A3DE
External IDsOMIM: 609900; GeneCards: APOBEC3D
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

140564

n/a

Ensembl

ENSG00000243811

n/a

UniProt

B2CML4

n/a

RefSeq (mRNA)

NM_152426
NM_001363781

n/a

RefSeq (protein)

NP_689639
NP_001350710

n/a

Location (UCSC)Chr 22: 39.02 – 39.03 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.[3][4]

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.[4]

Function

APOBEC3D is one of the human APOBEC3 enzymes involved in restriction of HIV-1.[5][6] HIV-1 Vif counteracts APOBEC3D by recruiting ubiquitin-ligase machinery that leads to its polyubiquitination and proteasomal degradation in virus-producing cells.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243811 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, et al. (February 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–296. doi:10.1006/geno.2002.6718. PMID 11863358.
  4. ^ a b "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".
  5. ^ a b Delviks-Frankenberry KA, Desimmie BA, Pathak VK (May 2020). "Structural Insights into APOBEC3-Mediated Lentiviral Restriction". Viruses. 12 (6): 587. doi:10.3390/v12060587. PMC 7354603. PMID 32471198.
  6. ^ a b Feng Y, Baig TT, Love RP, Chelico L (2014). "Suppression of APOBEC3-mediated restriction of HIV-1 by Vif". Frontiers in Microbiology. 5 450. doi:10.3389/fmicb.2014.00450. PMC 4144255. PMID 25206352.

Further reading

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