A House Divided follows the direct descendants of Letty Sanders, an enslaved woman who after arriving in Los Angeles, California in 1821 and became the wealthiest Black woman in the newly formed city. It centers on the present-day members of the highly esteemed Sanders family, Cameron Sanders (Lawrence Hilton-Jacobs) has raised his three children: Stephanie (Paula Jai Parker), Cameron, Jr. (Brad James), and Torrance (Steph Santana), in opulent wealth. After the sudden passing of his wife amidst a brewing government investigation into the business dealings of the family-owned bank, a new woman, Carissa Walker (Demetria McKinney) emerges from the shadows determined to be the next Mrs. Cameran Sanders. As secrets are uncovered and scandals emerge, the Sanders family will be forced to band together for the sake of their survival or risk the ultimate demise of their long-standing legacy.