Alexander Stark

Alexander Stark
Alma mater
Scientific career
Fieldsgene expression in development, transcription
Institutions
Robert B. Russell
Websitewww.imp.ac.at/groups/alexander-stark/

Alexander Stark (born September 1974) is a biochemist and computational biologist working on the regulation of gene expression in development.[1] He is a senior scientist at the Research Institute of Molecular Pathology (IMP) at the Vienna Biocenter and adjunct professor of the Medical University of Vienna.[2]

Early life and education

Alexander Stark grew up in Baden-Württemberg, Germany. He studied biochemistry at the University of Tübingen, and graduated with a diploma in biochemistry in 2000.[3] In 2001, he started to do research for doctoral studies in the group of Robert B. (Rob) Russell at the European Molecular Biology Laboratory (EMBL) and obtained his doctorate from the University of Cologne in 2004.[3] Stark remained at EMBL for one more year as a bridging postdoc.

Career

In 2005,[3] Stark became a postdoctoral researcher in the groups of Eric S. Lander and Manolis Kellis at the Broad Institute of MIT and Harvard University and the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) in Boston, USA. His postdoctoral research was supported by EMBO, HFSP, and the Schering Foundation.

In 2008, Stark became group leader at the Research Institute of Molecular Pathology (IMP) in Vienna and was promoted to senior scientist in 2015.[3][4] He was made adjunct professor of the Medical University of Vienna in 2017.[2]

Research

Alexander Stark studies the regulation of gene expression in response to developmental or environmental stimuli to learn how transcription and transcriptional networks define cellular and developmental programs.[5][1]

More specifically, he investigates how transcription is regulated at the level of enhancer and core-promoter DNA elements, and the transcription factor and cofactor proteins that mediate transcription activation. He uses genome-wide functional assays, bioinformatics, and mass spectrometry, and develops innovative reporter assays (such as STARR-seq) that provide direct functional readouts.[1]

Some of Stark's most cited publications include Principles of MicroRNA- Target Recognition,[6] bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila,[7] and Histone modifications at human enhancers reflect global cell-type-specific gene expression.[8]

Awards and achievements

Stark is on the editorial boards of Genes & Development[14] and Molecular Systems Biology.[15]

References

  1. ^ a b c "Alexander Stark - Systems biology of regulatory motifs & networks". The Research Institute of Molecular Pathology. Retrieved 2018-02-11.
  2. ^ a b "Alexander Stark". Research Institute of Molecular Pathology GmbH. IMP. Retrieved 2019-02-14.
  3. ^ a b c d "Alexander Stark". Stark Lab. Research Institute of Molecular Pathology. Retrieved 11 March 2019.
  4. ^ "2008 IMP Research Report" (PDF). imp.ac.at. Retrieved 29 May 2023.
  5. ^ "Deciphering the transcriptional cis-regulatory code". Stark Lab. 2018-02-05. Retrieved 2018-02-11.
  6. ^ Brennecke J, Stark A, Russell RB, Cohen SM (2005) Principles of MicroRNA–Target Recognition. PLoS Biol 3(3): e85. https://doi.org/10.1371/journal.pbio.0030085
  7. ^ Brennecke, Julius (4 April 2003). "bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila". Cell. 113 (1): 25–36. doi:10.1016/S0092-8674(03)00231-9. PMID 12679032. S2CID 17585984.
  8. ^ Heintzman, Nathaniel (7 May 2009). "Histone modifications at human enhancers reflect global cell-type-specific gene expression". Nature. 459 (7243): 108–112. Bibcode:2009Natur.459..108H. doi:10.1038/nature07829. PMC 2910248. PMID 19295514.
  9. ^ "IMP Scientist Alex Stark awarded an ERC Consolidator Grant". idw-online.de.
  10. ^ Pathology, The Research Institute of Molecular. "Press Release: EMBO Accolade for Alexander Stark".
  11. ^ "Find a Member". EMBO. Archived from the original on 2020-03-21. Retrieved 2018-01-05.
  12. ^ Pathology, The Research Institute of Molecular. "Alexander Stark among the world's most highly cited researchers".
  13. ^ "Find a Young Investigator". EMBO.
  14. ^ "Genes & Development -- About the Journal". genesdev.cshlp.org.
  15. ^ "Editors & Board - Molecular Systems Biology". msb.embopress.org.

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