The Alliance for Cannabis Therapeutics (ACT) is an organization supporting medical marijuana that was founded in 1981 by Robert C. Randall and Alice O'Leary.^[1] The Alliance was originally formed through Randall’s personal campaigning to access medical marijuana to treat his glaucoma. After being found not guilty of marijuana possession by reason of medical necessity and being included in a research program in which he received marijuana, Randall was the first person known to have successfully used medical necessity as a defense against a charge of marijuana possession in violation of the Controlled Substances Act.^[2] After Randall’s individual success in obtaining marijuana legally, the Alliance for Cannabis Therapeutics sought to drive the movement in politics and public media for widespread medical cannabis usage.

The Alliance for Cannabis Therapeutics was started in 1981 by Randall and his wife, Alice O-Leary-Randall. The ACT'S goal was to establish federal access to marijuana for individuals with serious and/or life threatening conditions, a polarizing conversation during the time period.^[1] After extensive research and lobbying efforts, bill H.R. 4498 was introduced in the House of Representatives in September of 1981.[1] Despite being sponsored and cosponsored by 85 house republicans, the scheduled hearings were never held. Committee Chairman Henry Waxman, a democrat from California, never formally held hearings in part due to his own agenda of establishing heroin as a federally regulated therapeutic agent and worried that the ACT bill would undermine the cause. [2]The Alliance continued to publicly advocate for medical usage efforts in the United States despite this ruling.

Clare Hodges aka Elizabeth Brice founded the UK Alliance for Cannabis Therapeutics (ACT) after contacting the Alice O'Leary and Robert Randall in 1992 about the medical benefits of marijuana for individuals suffering from multiple sclerosis.^[3] Using the pseudonym Clare Hodges, Brice wrote extensively about her cannabis usage and the positive effects on her mental and physical health dealing with MS. Similarly to Randall, Brice claimed that medicinal usage of cannabis drastically improved her life and enabled her to perform everyday tasks otherwise extremely difficult while living with MS. Randall, Brice, and O’Leary focused political pressure on the UK government through this organization. The renewed ACT focused heavily on lobbying efforts to move cannabis from a Schedule I to a Schedule II drug, in order to restore cannabis's status as a legal medicine.

Randall and O'Leary were still active in proposing medicinal cannabis usage in the US before the UK chapter of the ACT was formed. The group participated in the 1986 hearings on cannabis rescheduling in the United States. ACT along with NORML petitioned for review of the final order of the Administrator of the Drug Enforcement Administration which followed the hearings. See Alliance for Cannabis Therapeutics v. DEA, 930 F.2d 936 (D.C.Cir.1991)^[4] The ACT during this time period became very involved in the British Medicine Association Report, taking delegations of esteemed people such as Professor Patrick Wall and Lord Whaddon to confer with the British Ministry of Health.[3] Following the director of the company GW Pharmaceuticals joining the lobby delegation in 1997, the pharmaceutical company was granted access by British Department of Health Minister Paul Boateng to grow cannabis for medical research. [4]Other offshoot organizations relating to medical marijuana grew forward from the ACT, such as the Marijuana AIDS Research Service in the 1990s designed by Randall to help AIDS patients to receive medicinal cannabis through various FDA programs. [5]

The ACT is now widely recognized as one of the most influential groups in the promotion of medicinal and recreation cannabis, both in the US and UK. In the UK, cannabis was rescheduled from a Schedule I to a Schedule II substance in November of 2018, with cannabis possession currently legal for those with clinical need. As of 2024, medicinal cannabis is legal in 38 US states, with recreational use legal in 24 states. Despite Randall and Brice both passing away before public medicinal legalization, their contribution to the movement through the ACT was extremely influential in promoting medicinal cannabis usage.

1. ^ ^{a b} "About Robert C. Randall, father of medical marijuana movement". Alice O'Leary Randall & Project 50. Retrieved 2024-11-20.
2. ^ "Archived copy" (PDF). Archived from the original (PDF) on 2009-02-05. Retrieved 2009-02-04.{{cite web}}: CS1 maint: archived copy as title (link)
3. ^ Rosner, Abbie. "A Conversation With Veteran Cannabis Activist Alice O'Leary Randall". Forbes. Retrieved 2023-08-19.
4. ^ "930 F.2d 936: Alliance for Cannabis Therapeutics, Petitioner, v. Drug Enforcement Administration, Respondent.the National Organization for the Reform of Marijuana Laws, Petitioner, v. Drug Enforcement Administration, Respondent :: US Court of Appeals Cases :: Justia". Cases.justia.com. Retrieved 2011-04-20.

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