Aquaretic

An aquaretic is a novel class of drug that is used to promote aquaresis, the excretion of water without electrolyte loss.^[1] Strictly speaking, aquaretics are not diuretics but are sometimes classified as such.

Aquaresis is preferable to diuresis in the treatment of hyponatremia.^{[citation needed]}

Aquaretics increase urine output without increasing sodium and chloride excretion, thus causing an increase in urine whilst retaining electrolytes.^[2]

A number of herbal medicines are classified as aquaretics, for example common horsetail or common nettle leaves.^[3]

Synthetic aquaretics are vasopressin receptor antagonists and include conivaptan, tolvaptan, demeclocycline, and mozavaptan (OPC-31260), as well as lithium. Conivaptan hydrochloride and tolvaptan have been approved by the FDA for treating syndrome of inappropriate antidiuretic hormone.^[4][5] Mozavaptan is approved in Japan.^{[citation needed]}

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