Born in Carnaúba dos Dantas, Ayrton Lucas started his youth career with the academy of ABC Futebol Clube and joined the academy of Fluminense in October 2014. On 8 August 2015, he was promoted to the senior team.[3] However, he soon lost his position to Léo Pelé and Giovanni and was subsequently loaned out to Madureira on 23 February 2016 for the Campeonato Carioca.[4] In April, he returned to his parent club.[5]
On 4 January 2017, Ayrton Lucas was loaned out to Londrina.[6] Twenty-five days later, he made his first team debut in a 1–1 draw against Prudentópolis.[7] On 13 April, he scored his first goal for the club in a 3–0 victory against Rio Branco.[8] Londrina went on to win the Primeira Liga, with Ayrton Lucas finding the net during the penalty shoot-out in the final against Atlético Mineiro.[9]
After returning from loan, Ayrton Lucas was included in the Fluminense squad for the 2018 Florida Cup.[10] He was issued the number 6 jersey for the Série A season.[11]
Spartak Moscow
On 17 December 2018, Ayrton Lucas signed a long-term contract with Russian club Spartak Moscow.[12] He scored his first goal for Spartak against FC Tambov on 26 September 2020. He followed up with his second in the same match and led the team to a 2–0 win.[citation needed]
On 19 January 2022, he extended his contract with Spartak until May 2026.[13]
Flamengo
On 31 March 2022, Ayrton Lucas joined Flamengo on loan until the end of 2022, with a conditional obligation to buy.[14]
In 2022 Ayrton Lucas had the best season of his career winning Copa do Brasil and Copa Libertadores with a total of six assists and two goals in 41 appearances for Flamengo.[15]
On 16 December 2022, Flamengo announced the permanent transfer of Ayrton Lucas with a €7m transfer fee, he signed a contract with the club until December 2027.[16]