BMP2K

BMP2K
Identifiers
AliasesBMP2K, BIKE, HRIHFB2017, BMP2 inducible kinase
External IDsOMIM: 617648; MGI: 2155456; GeneCards: BMP2K
Available structures
PDBOrtholog search: PDBe RCSB
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.7.11.1↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

55589

140780

Ensembl

ENSG00000138756

ENSMUSG00000034663

UniProt

Q9NSY1

Q91Z96

RefSeq (mRNA)

NM_017593
NM_198892

NM_080708

RefSeq (protein)

NP_060063
NP_942595

NP_542439

Location (UCSC)Chr 4: 78.78 – 78.92 MbChr 5: 97.15 – 97.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[5]

Function

This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138756 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034663 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BMP2K BMP2 inducible kinase".

Further reading


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