The station opened along with the Manassas Line on June 22, 1992.[1] A large parking garage and bus stands were added in mid-2008 as a $28 million project.[3]
On October 1, 2009, one Amtrak Northeast Regional round trip was extended to Lynchburg. As with Northeast Regional trains on the Fredericksburg Line, trains would stop for VRE passengers under a cross-honoring agreement between Amtrak and VRE.[3] On January 18, 2010, Burke Centre became a full Amtrak stop, with passengers allowed to book travel to and from the station in both directions.[4] Amtrak Cardinal and Crescent trains pass through but do not stop.