CCDC90B

CCDC90B
Identifiers
AliasesCCDC90B, MDS011, MDS025, coiled-coil domain containing 90B
External IDsMGI: 1913615; GeneCards: CCDC90B
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

60492

66365

Ensembl

ENSG00000137500

ENSMUSG00000030613

UniProt

Q9GZT6

Q8C3X2

RefSeq (mRNA)

NM_001162918
NM_025515

RefSeq (protein)

NP_001156390
NP_079791

Location (UCSC)Chr 11: 83.26 – 83.29 MbChr 7: 92.21 – 92.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene. It is a mitochondrial calcium uniporter binding protein.[5]

Gene

CCDC90B is located on chromosome 11 in humans. It is neighbored by:[6]

  • PCF11, a mammalian pre-mRNA cleavage complex 2 protein
  • ANKRD42, ankyrin repeat protein involved with calcium ion bonding
  • BC070093
  • DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Structure

This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

Properties

Post-translation modifications:[7]

Chloroplast transit peptides: None
Signal pepties: None
C-mannosylation sites: None
N-glycosylation sites: None
Mitochondrial targeting: Yes
Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137500 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030613 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adlakha J, Karamichali I, Sangwallek J, Deiss S, Bär K, Coles M, et al. (March 2019). "Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles". Structure. 27 (3): 464–475.e6. doi:10.1016/j.str.2018.11.004. PMID 30612859.
  6. ^ "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. Retrieved 2009-05-14.
  7. ^ "ExPASy". SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.

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