CDCA5

CDCA5
Identifiers
AliasesCDCA5, SORORIN, cell division cycle associated 5
External IDsOMIM: 609374; MGI: 1915099; GeneCards: CDCA5
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

113130

67849

Ensembl

ENSG00000146670

ENSMUSG00000024791

UniProt

Q96FF9

Q9CPY3

RefSeq (mRNA)

NM_080668

NM_026410

RefSeq (protein)

NP_542399

NP_080686

Location (UCSC)Chr 11: 65.07 – 65.08 MbChr 19: 6.14 – 6.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sororin is a protein that in humans is encoded by the CDCA5 gene.[5][6][7]

Function

Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.[8]

Clinical significance

Transactivation of Sororin and its phosphorylation at Ser209 by ERK play an important role in lung cancer proliferation.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146670 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024791 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Walker MG (Aug 2002). "Drug target discovery by gene expression analysis: cell cycle genes". Curr Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893.
  6. ^ Rankin S, Ayad NG, Kirschner MW (Apr 2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
  7. ^ "Entrez Gene: CDCA5 cell division cycle associated 5".
  8. ^ Schmitz J, Watrin E, Lénárt P, Mechtler K, Peters J (Apr 2007). "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase". Curr Biol. 17 (7): 630–6. Bibcode:2007CBio...17..630S. doi:10.1016/j.cub.2007.02.029. hdl:21.11116/0000-0002-101C-D. PMID 17349791. S2CID 11988060.
  9. ^ Nguyen M, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y (Jul 2010). "Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis". Cancer Res. 70 (13): 5337–47. doi:10.1158/0008-5472.CAN-09-4372. PMID 20551060.

Further reading

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