Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2gene.[5][6]
The protein encoded by this gene is a neuron-specific activator of CDK5kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.[6]
Humbert S, Dhavan R, Tsai L (March 2000). "p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton". Journal of Cell Science. 113 (6): 975–83. doi:10.1242/jcs.113.6.975. PMID10683146.
Muravenko OV, Gizatullin RZ, Protopopov AI, Kashuba VI, Zabarovsky ER, Zelenin AV (2000). "Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 160–1. doi:10.1159/000015602. PMID10965112. S2CID83701584.
Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID12761178.
Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M (2005). "Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease". Neurobiology of Aging. 26 (8): 1145–51. doi:10.1016/j.neurobiolaging.2004.10.003. PMID15917097. S2CID25396010.
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