CHST4

CHST4

Identifiers

CHST4, GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST, carbohydrate sulfotransferase 4

External IDs

MGI: 1349479; GeneCards: CHST4

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q22.2	Start	71,525,233 bp^[1]
Band	16q22.2	End	71,538,748 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 D3	Start	110,755,785 bp^[2]
Band	8\|8 D3	End	110,766,372 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

gallbladder

pancreatic ductal cell

testicle

islet of Langerhans

mucosa of ileum

body of pancreas

epithelium of bronchus

secondary oocyte

nasal epithelium

bronchial epithelial cell

Top expressed in

colon

left colon

duodenum

morula

urethra

jejunum

ileum

epithelium of stomach

intestinal villus

secondary oocyte

More reference expression data


More reference expression data

Gene ontology
Molecular function	transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity
Cellular component	integral component of membrane Golgi apparatus intrinsic component of Golgi membrane membrane Golgi membrane trans-Golgi network
Biological process	cell-cell signaling cell adhesion immune response O-glycan processing sulfur compound metabolic process protein sulfation inflammatory response N-acetylglucosamine metabolic process keratan sulfate biosynthetic process carbohydrate metabolic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


10164


26887


ENSG00000140835


ENSMUSG00000035930


Q8NCG5


Q9R1I1

RefSeq (mRNA)


NM_005769 NM_001166395


NM_011998

RefSeq (protein)


NP_001159867 NP_005760


NP_036128

Location (UCSC)

Chr 16: 71.53 – 71.54 Mb

Chr 8: 110.76 – 110.77 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140835 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035930 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (Jul 1999). "Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin". J Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
^ "Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4".

Further reading

Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
Hemmerich S, Lee JK, Bhakta S, et al. (2001). "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family". Glycobiology. 11 (1): 75–87. doi:10.1093/glycob/11.1.75. PMID 11181564.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. doi:10.1189/jlb.69.4.565. PMID 11310842. S2CID 8888883.
Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase". Cell. 105 (7): 957–69. doi:10.1016/S0092-8674(01)00394-4. PMID 11439191. S2CID 18674112.
Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression". J. Biol. Chem. 277 (6): 3979–84. doi:10.1074/jbc.M106587200. PMID 11726653.
Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma". Glycobiology. 12 (6): 379–88. doi:10.1093/glycob/12.6.379. PMID 12107080.
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate". J. Biol. Chem. 277 (45): 42505–13. doi:10.1074/jbc.M207412200. PMID 12218059.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity". J. Biol. Chem. 279 (38): 40035–43. doi:10.1074/jbc.M405709200. PMID 15220337.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Timson G, Banavali S, Gutierrez MI, et al. (2006). "High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia". Cancer Lett. 242 (2): 239–44. doi:10.1016/j.canlet.2005.11.012. PMID 16386360.

External links

CHST4 human gene location in the UCSC Genome Browser.
CHST4 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

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