CIR1

CIRSR
Identifiers
AliasesCIRSR, CIR, corepressor interacting with RBPJ, 1, corepressor interacting with RBPJ, CIR1, CIR1, Corepressor Of RBPJ And Splicing Regulator
External IDsOMIM: 605228; MGI: 1914185; GeneCards: CIRSR
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9541

66935

Ensembl

ENSG00000138433

ENSMUSG00000041777

UniProt

Q86X95

Q9DA19

RefSeq (mRNA)

NM_199075
NM_004882

NM_025854

RefSeq (protein)

NP_004873

NP_080130

Location (UCSC)Chr 2: 174.35 – 174.4 MbChr 2: 73.11 – 73.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Corepressor of RBPJ and splicing regulator is a protein that in humans is encoded by the CIRSR gene (previously CIR1).[5][6][7][8]

Interactions

CIR (gene) has been shown to interact with SNW1.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138433 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041777 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (Feb 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Experimental Cell Research. 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.
  6. ^ Zhang J, Chen H, Weinmaster G, Hayward SD (Mar 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC". Journal of Virology. 75 (6): 2946–56. doi:10.1128/JVI.75.6.2946-2956.2001. PMC 115921. PMID 11222720.
  7. ^ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
  8. ^ "Entrez Gene: CIR CBF1 interacting corepressor".
  9. ^ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.

Further reading


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