CPE may refer to:

• Carbapenemase-producing enterobacteriaceae, a "superbug" resistant to antibiotics
• Carboxypeptidase E, an enzyme involved in the biosynthesis of neuropeptides and peptide hormones
• Clostridium perfringens enterotoxin, a contributor to food poisoning
• Cytopathic effect, changes in cells caused by viruses
• Cytoplasmic polyadenylation element, an RNA sequence
• Chlorinated polyethylene, a thermoplastic polymer
• Core promoter element, in DNA, initiating gene transcription

• Customer-premises equipment, any equipment which is the property of the network operator and located on the customer premises

• Carnian pluvial episode/event, a climatic episode and minor extinction-radiation event in the Triassic
• Carbon paste electrode, a special type of electrodes used in electrochemistry
• Charged-particle equilibrium
• Computer engineering
• Constant phase element of an equivalent electrical circuit

• Certificate of Primary Education, an academic qualification in Mauritius awarded upon the completion of primary school
• Certificate of Proficiency in English, a general English exam provided by the University of Cambridge
• Certified Professional Electrologist, board certification credential for permanent hair removal specialists
• Clinical pastoral education, training in pastoral care for religious workers
• Coalition on Psychiatric Emergencies, a coalition of organizations dedicated to improving care for mental health emergencies
• Common Professional Examination, a course which allows non-law graduates in England and Wales to convert to law after university
• Continuing professional education, or continuing professional development, is the means by which professionals maintain and develop the qualities required in their working lives
• École supérieure de chimie physique électronique de Lyon (CPE Lyon), a French engineering school
• Kentucky Council on Postsecondary Education
• Committee for Private Education, an accreditation body for private schools and tertiary education providers in Singapore

• Centrally planned economy
• First Employment Contract (contrat première embauche), a French form of work contract, retracted by the government in Spring 2006
• Cost Per Enplanement, a term used in commercial aviation regarding airport costs
• Cost per engagement, an online advertising selling model in which the vendor defines the "engagement" as form of currency or metric

• Centristi per l'Europa (Centrists for Europe), an Italian political party
• Communist Party of England (Marxist-Leninist), former name of Revolutionary Communist Party of Britain (Marxist–Leninist)
• CPE (investment firm), Chinese company
• Creative Power Entertaining, Chinese animation company

• Chinese Pidgin English, a pidgin language spoken in parts of China in the 17th to 19th centuries.
• Common Platform Enumeration, a component of the Security Content Automation Protocol (SCAP)
• CPE, IATA airport code for Ing. Alberto Acuña Ongay International Airport in Campeche, Mexico
• Carl Philipp Emanuel Bach (1714–1788), German Classical period musician and composer
• Communist Party of Estonia

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