CPLX1

CPLX1
Identifiers
AliasesCPLX1, CPX-I, CPX1, complexin 1, EIEE63, DEE63
External IDsOMIM: 605032; MGI: 104727; GeneCards: CPLX1
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

10815

12889

Ensembl

ENSG00000168993

ENSMUSG00000033615

UniProt

O14810

P63040

RefSeq (mRNA)

NM_006651

NM_007756

RefSeq (protein)

NP_006642

NP_031782

Location (UCSC)Chr 4: 0.78 – 0.83 MbChr 5: 108.67 – 108.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.[5][6]

Function

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.[6]

Interactions

CPLX1 has been shown to interact with SNAP-25[7][8] and STX1A.[9][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168993 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033615 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
  6. ^ a b "Entrez Gene: CPLX1 complexin 1".
  7. ^ a b Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227. S2CID 17878965.
  8. ^ a b Hu K, Carroll J, Rickman C, Davletov B (Nov 2002). "Action of complexin on SNARE complex". The Journal of Biological Chemistry. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.
  9. ^ Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". The EMBO Journal. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.

Further reading

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