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CPNE6
Identifiers
Aliases	CPNE6, copine 6
External IDs	OMIM: 605688; MGI: 1334445; GeneCards: CPNE6
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,078,100 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,754,888 bp
RNA expression pattern
	Top expressed in
	temporal lobe; ; amygdala; ; right hemisphere of cerebellum; ; hippocampus proper; ; superior frontal gyrus; ; right frontal lobe; ; nucleus accumbens; ; anterior cingulate cortex; ; prefrontal cortex; ; putamen;
	Top expressed in
	CA3 field; ; subiculum; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; entorhinal cortex; ; perirhinal cortex; ; hippocampus proper; ; anterior amygdaloid area; ; Region I of hippocampus proper; ; facial motor nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; transporter activity; phosphatidylserine binding; protein binding; calcium-dependent phospholipid binding;
Cellular component	cytoplasm; endosome; perikaryon; cell projection; membrane; clathrin-coated endocytic vesicle; plasma membrane; axon; dendrite; extracellular exosome; cytoplasmic vesicle; clathrin-coated vesicle;
Biological process	cellular response to calcium ion; cell differentiation; lipid metabolism; nervous system development; glycerophospholipid biosynthetic process; positive regulation of dendrite extension; vesicle-mediated transport; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9362
	12891
	ENSG00000100884
	ENSMUSG00000022212
	O95741
	Q9Z140
	NM_001280558; NM_006032
	NM_001136057; NM_001146183; NM_009947; NM_001360193
	NP_001267487; NP_006023
	NP_001129529; NP_001139655; NP_034077; NP_001347122
	Wikidata
View/Edit Human	View/Edit Mouse

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.^[5]^[6]

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100884 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022212 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakayama T, Yaoi T, Yasui M, Kuwajima G (Jul 1998). "N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression". FEBS Lett. 428 (1–2): 80–4. doi:10.1016/S0014-5793(98)00497-9. PMID 9645480. S2CID 27969998.
^ ^a ^b "Entrez Gene: CPNE6 copine VI (neuronal)".

External links

Human CPNE6 genome location and CPNE6 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nakayama T, Yaoi T, Kuwajima G (1999). "Localization and subcellular distribution of N-copine in mouse brain". J. Neurochem. 72 (1): 373–9. doi:10.1046/j.1471-4159.1999.0720373.x. PMID 9886090.
Nakayama T, Yaoi T, Kuwajima G, et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Lett. 453 (1–2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379.
Caudell EG, Caudell JJ, Tang CH, et al. (2000). "Characterization of human copine III as a phosphoprotein with associated kinase activity". Biochemistry. 39 (42): 13034–43. doi:10.1021/bi001250v. PMID 11041869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100884 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022212 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9645480-5] Nakayama T, Yaoi T, Yasui M, Kuwajima G (Jul 1998). "N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression". FEBS Lett. 428 (1–2): 80–4. doi:10.1016/S0014-5793(98)00497-9. PMID 9645480. S2CID 27969998.

[entrez-6] "Entrez Gene: CPNE6 copine VI (neuronal)".

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CPNE6

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