CRLF3

CRLF3
Identifiers
AliasesCRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDsOMIM: 614853; MGI: 1860086; GeneCards: CRLF3
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

51379

54394

Ensembl

ENSG00000176390

ENSMUSG00000017561

UniProt

Q8IUI8

Q9Z2L7

RefSeq (mRNA)

NM_015986

NM_001277106
NM_018776

RefSeq (protein)

NP_057070

NP_001264035
NP_061246

Location (UCSC)Chr 17: 30.77 – 30.82 MbChr 11: 79.94 – 79.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[5]

Function

Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.[6]

Origin

Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176390 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017561 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: cytokine receptor-like factor 3".
  6. ^ Hahn N, Knorr DY, Liebig J, Wüstefeld L, Peters K, Büscher M, et al. (2017). "The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor". Frontiers in Molecular Neuroscience. 10 223. doi:10.3389/fnmol.2017.00223. PMC 5509957. PMID 28769759.
  7. ^ Hahn N, Büschgens L, Schwedhelm-Domeyer N, Bank S, Geurten BR, Neugebauer P, et al. (2019). "The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts". Frontiers in Molecular Neuroscience. 12 251. doi:10.3389/fnmol.2019.00251. PMC 6797617. PMID 31680856.
  8. ^ Liongue C, Ward AC (July 2007). "Evolution of Class I cytokine receptors". BMC Evolutionary Biology. 7 (1): 120. Bibcode:2007BMCEE...7..120L. doi:10.1186/1471-2148-7-120. PMC 1963337. PMID 17640376.

Further reading

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