CSTF2T

CSTF2T

Identifiers

CSTF2T, CstF-64T, cleavage stimulation factor subunit 2, tau variant, cleavage stimulation factor subunit 2 tau variant

External IDs

OMIM: 611968; MGI: 1932622; GeneCards: CSTF2T

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q21.1	Start	51,695,486 bp^[1]
Band	10q21.1	End	51,699,595 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C1	Start	31,060,237 bp^[2]
Band	19\|19 C1	End	31,064,469 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

endothelial cell

germinal epithelium

Epithelium of choroid plexus

parietal pleura

pons

islet of Langerhans

ganglionic eminence

corpus callosum

Descending thoracic aorta

subthalamic nucleus

Top expressed in

pineal gland

medial ganglionic eminence

olfactory tubercle

habenula

lateral septal nucleus

anterior amygdaloid area

subiculum

lobe of cerebellum

cerebellar vermis

median eminence

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding mRNA binding nucleic acid binding RNA binding
Cellular component	mRNA cleavage and polyadenylation specificity factor complex intracellular anatomical structure nucleus nucleoplasm
Biological process	mRNA processing pre-mRNA cleavage required for polyadenylation mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA 3'-end processing
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23283


83410


ENSG00000177613


ENSMUSG00000053536


Q9H0L4


Q8C7E9

RefSeq (mRNA)


NM_015235


NM_031249

RefSeq (protein)


NP_056050


NP_112539

Location (UCSC)

Chr 10: 51.7 – 51.7 Mb

Chr 19: 31.06 – 31.06 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Cleavage stimulation factor 64 kDa subunit, tau variant is a protein that in humans is encoded by the CSTF2T gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177613 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053536 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dass B, McDaniel L, Schultz RA, Attaya E, MacDonald CC (Oct 2002). "The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein tauCstF-64, lacks introns and may be associated with male sterility". Genomics. 80 (5): 509–14. doi:10.1016/S0888-7543(02)96862-X. PMID 12408968.
^ Dass B, McMahon KW, Jenkins NA, Gilbert DJ, Copeland NG, MacDonald CC (May 2001). "The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice". J Biol Chem. 276 (11): 8044–50. doi:10.1074/jbc.M009091200. PMID 11113135.
^ "Entrez Gene: CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant".

External links

Human CSTF2T genome location and CSTF2T gene details page in the UCSC Genome Browser.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pérez Cañadillas JM, Varani G (2003). "Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein". EMBO J. 22 (11): 2821–30. doi:10.1093/emboj/cdg259. PMC 156756. PMID 12773396.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhao X, Oberg D, Rush M, et al. (2005). "A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein". J. Virol. 79 (7): 4270–88. doi:10.1128/JVI.79.7.4270-4288.2005. PMC 1061554. PMID 15767428.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

v t e PDB gallery
1p1t: NMR Structure of the N-terminal RRM domain of Cleavage stimulation factor 64 KDa subunit 2j8p: NMR STRUCTURE OF C-TERMINAL DOMAIN OF HUMAN CSTF-64

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