CYTH3

CYTH3
Identifiers
AliasesCYTH3, ARNO3, GRP1, PSCD3, cytohesin 3, cytohesin-3
External IDsOMIM: 605081; MGI: 1335107; GeneCards: CYTH3
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9265

19159

Ensembl

ENSG00000008256

ENSMUSG00000018001

UniProt

O43739

O08967

RefSeq (mRNA)

NM_004227

NM_001163548
NM_011182

RefSeq (protein)

NP_004218
NP_001354509
NP_001354510
NP_001354511

NP_001157020
NP_035312

Location (UCSC)Chr 7: 6.16 – 6.27 MbChr 5: 143.61 – 143.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.[5][6]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008256 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018001 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP (Apr 1997). "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains". Science. 275 (5308): 1927–30. doi:10.1126/science.275.5308.1927. PMID 9072969. S2CID 40523716.
  6. ^ a b "Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3".

Further reading


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