Florida State began the season against Alabama in the Chick-fil-a Kickoff Game. Akers rushed for 30 yards on 10 attempts in his college debut. They would lose, 24–7.[9] Akers first 100-yard game came against Miami (FL), where he rushed for 129 yards on 14 carries in a 24–20 loss.[10] Against Duke a week later, Akers scored his first college touchdown on a 46-yard touchdown run to beat the Blue Devils, 17–10.[11] In a game against Syracuse, Akers rushed for 199 yards on 22 carries and two touchdowns.[12] Against Louisiana–Monroe in the final regular season game, Akers rushed for 117 yards on 19 carries and two touchdowns.[13] After the 2017 Independence Bowl, Akers totals on the season went to 194 attempts for 1,025 yards and seven touchdowns. He also had 16 receptions for 116 yards and a touchdown. His rushing total broke the FSU freshman record previously held by Dalvin Cook in 2014 when he rushed for 1,008 yards.[14] Akers was named Third-Team All-Atlantic Coast Conference (ACC) at the end of the season.[15]
2018 season
Akers was again the starter for the 2018 season. He was also named Preseason All-ACC.[16] Akers didn't have a very good season, not having a 100-yard performance until second to last game of the season against Boston College, where he rushed for 110 yards on 14 carries and a touchdown.[17] Akers finished the season with 706 yards on 161 attempts and six touchdowns as well as 23 receptions for 145 yards and two touchdowns.
2019 season
In Florida State's second game of the season, Akers rushed for 193 yards on 36 carries and a pair of touchdowns. He also had five receptions for 55 yards and a touchdown in their 45–44 win over Louisiana–Monroe. His 36 carries was a program record.[18] Against Louisville, Akers had 112 rushing yards and three rushing touchdowns in a 35–24 win.[19] Against Wake Forest, Akers carried the ball 30 times for 157 yards and a touchdown as well as four receptions for 42 yards and another touchdown.[20] A week later against Syracuse, Akers had 20 carries for 144 yards and four touchdowns to rout the Orange, 35–17. His four touchdowns tied the program record.[21] In Akers final game against Florida, he had 17 rush attempts for 102 yards and a touchdown in a 40–17 loss.[22]
On December 14, 2019, Akers announced he would be skipping the Sun Bowl to enter the 2020 NFL draft.[23] Akers finished his season tied for seventh in single-season touchdown carries with 14 and seventh in career rushing touchdowns with 27. His 1,144 yards were ranked sixth for a single-season and his 2,875 career rushing yards rank sixth in program history.[24] He was also named Second-Team All-ACC at the end of the season.[25]
Akers was selected by the Los Angeles Rams in the second round, 52nd overall, in the 2020 NFL Draft.[29]
In Week 11 against the Tampa Bay Buccaneers, Akers scored his first career touchdown on a four-yard reception in the third quarter in a 27–24 victory.[30][31] In Week 14 against the New England Patriots, Akers rushed for 171 yards on 29 attempts which marked the sixth-most rushing yards by any NFL player in a single game during the 2020 season and fourth-most by a Rams rookie in a single game in franchise history. The Rams won the game by a score of 24–3.[32][33] Akers was named the NFC Offensive Player of the Week for his performance in Week 14.[34]
In the Wild Card Round of the NFL playoffs against the Seattle Seahawks, Akers rushed for 131 yards and a touchdown and caught 2 passes for 45 yards during the 30–20 win.[35] In the Divisional Round of the playoffs against the Green Bay Packers, Akers rushed for 90 yards and a touchdown during the 32–18 loss.[36]
On July 20, 2021, Akers tore his Achilles tendon while working out shortly before the start of training camp. Akers was expected to be sidelined for the entire 2021 season,[37] as he was placed on the reserve/non-football injury list to start the season. However, he was one of the first players to receive the SpeedBridge surgery, shortening his recovery time from 12 months to five months, and was activated to the active roster on December 25, 2021.[38] Akers returned to action in Week 18 against the San Francisco 49ers.[39] In the Super Bowl, Akers had 13 carries for 21 rushing yards and three receptions for 14 receiving yards in the Rams 23–20 victory against the Cincinnati Bengals.[40]
Akers was expected to start Week 1 but ended up only getting three rushing attempts for three yards. Akers requested a trade from the Rams after Week 5 and did not play in the Rams' next two games. Akers returned to practice on November 3 and later denied requesting a trade.[41]
Against the Denver Broncos in Week 16, Akers rushed for 118 yards and three touchdowns in the 51–14 win.[42] He rushed for 123 yards on 19 carries against the Los Angeles Chargers in Week 17 and 104 yards on 21 carries against the Seahawks in Week 18 and three catches for 24 receiving yards, finishing the season with three consecutive 100-yard rushing games.[43][44] He finished the 2022 season with 188 carries for 786 rushing yards and seven rushing touchdowns to go along with 13 receptions for 117 receiving yards in 15 games and nine starts.[45]
Akers began the season as the Rams' starting running back in Week 1 at the Seahawks. He carried the ball 22 times for 29 yards and scored on a 1-yard touchdown run in the fourth quarter of Los Angeles's 30–13 season-opening win. For unspecified reasons, Akers was inactive before the Week 2 game against the 49ers, with Kyren Williams making the start at running back.[46]
Minnesota Vikings (first stint)
On September 21, 2023, the Rams traded Akers and a conditional 2026 seventh-round draft pick to the Minnesota Vikings in exchange for a conditional 2026 sixth-round pick.[47][48][49] Akers was announced as inactive for Week 3.[50] In his Vikings debut against the Carolina Panthers, Akers rushed for 40 yards on five attempts as well as two catches for 11 yards. The Vikings would win, 21–13.[51] But, in Week 9 against the Atlanta Falcons, Akers suffered an injury to his left Achilles.[52] He was placed on the injured reserve list on November 8, 2023.[53]
On October 15, 2024, the Texans traded Akers and a 2026 conditional seventh-round draft pick to the Vikings in exchange for a conditional 2026 sixth-round pick.[55]