Upon joining River Plate, Isola originally played as an inside left, a position now known as a left winger or attacking midfielder.[5]
However, due to a lack of goalkeepers, Isola stepped into the role and quickly made it his own. With River Plate, he scored two goals from penalties during his career—one as a goalkeeper on Sunday, April 5, 1914, against Banfield, and another as an outfield player on Sunday, November 22, 1918, against Porteño.[5]