In May 1913 Casale became the first Italian club to defeat an English professional team when they beat Reading F.C. 2–1.[3] Reading won all the other games on this tour, defeating Genoa, Milan, Pro Vercelli, and even the Italy national team.
In the following season, Casale won their first and only national title.[3] Italian football was then organized on a regional basis and the national championship was divided into three stages. Casale topped the Ligurian-Piedmontese division and proceeded, along with second-placed Genoa, to compete in a division comprising the top northern teams, the others being Inter Milan, Juventus, Vicenza and Verona. Having won that division, Casale defeated central-southern champions Lazio 7–1, 0–2 in the two-leg final.[2][3]
After World War I, Casale remained in the top division for a couple of decades, representing what had been the cradle of early Italian football.[2]
With the development of professionalism, Casale was progressively relegated to lower divisions, 1934 being their last year in Serie A.[3] The club was later refounded twice, in 1993 and 2013, after financial problems. In 2013, it took the current name of Casale Foot Ball Club.[4]
A heated rivalry exists between the fans of Casale and Alessandria.
Five players who appeared in the scudetto-winning team of 1913–14 played in the Italy national team, all making their international debuts between 1912 and 1914:[5]
Eraldo Monzeglio, later to represent Italy on numerous occasions, including the 1934 and 1938 World Cups, made his Serie A debut with Casale in 1923–24. The following season, however, he moved to Bologna.[9]