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DACH2
Identifiers
Aliases	DACH2, dachshund family transcription factor 2
External IDs	OMIM: 300608; MGI: 1890446; GeneCards: DACH2
Gene location (Human)
Chr.	X chromosome (human)
End	86,832,604 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	112,746,083 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; entorhinal cortex; ; superior frontal gyrus; ; postcentral gyrus; ; nucleus accumbens; ; ventricular zone; ; hippocampus proper; ; prefrontal cortex;
	Top expressed in
	vas deferens; ; vestibular membrane of cochlear duct; ; saccule; ; otic vesicle; ; genital tubercle; ; digastric muscle; ; vestibular sensory epithelium; ; iris; ; medial ganglionic eminence; ; urachus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II general transcription initiation factor activity;
Cellular component	nucleus; transcription regulator complex;
Biological process	development of primary female sexual characteristics; transcription, DNA-templated; regulation of transcription, DNA-templated; multicellular organism development; RNA polymerase II preinitiation complex assembly; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	117154
	93837
	ENSG00000126733
	ENSMUSG00000025592
	Q96NX9
	Q925Q8
	NM_001139514; NM_001139515; NM_053281
	NM_001142570; NM_001289732; NM_001289733; NM_001289734; NM_033605
	NP_001132986; NP_001132987; NP_444511
	NP_001136042; NP_001276661; NP_001276662; NP_001276663; NP_291083
	Wikidata
View/Edit Human	View/Edit Mouse

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.^[5]

Function

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in the regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126733 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025592 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Multiple transcript variants encoding different isoforms have been found for this gene. "Entrez Gene: Dachshund homolog 2 (Drosophila)". Retrieved 2012-04-15.

Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini MC, Battaglia R, Marozzi A, Vegetti W, Dalprà L, Crosignani PG, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D (Dec 2004). "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B". Human Reproduction. 19 (12): 2759–66. doi:10.1093/humrep/deh502. PMID 15459172.
Poulin F, Nobrega MA, Plajzer-Frick I, Holt A, Afzal V, Rubin EM, Pennacchio LA (Jun 2005). "In vivo characterization of a vertebrate ultraconserved enhancer". Genomics. 85 (6): 774–81. doi:10.1016/j.ygeno.2005.03.003. PMID 15885503. S2CID 21888183.
Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G (Apr 2001). "Characterization of mouse Dach2, a homologue of Drosophila dachshund". Mechanisms of Development. 102 (1–2): 169–79. doi:10.1016/s0925-4773(01)00307-0. PMID 11287190.
Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I (Sep 2006). "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation". The EMBO Journal. 25 (17): 3955–65. doi:10.1038/sj.emboj.7601273. PMC 1560355. PMID 16917507.
Prueitt RL, Chen H, Barnes RI, Zinn AR (2002). "Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes". Cytogenetic and Genome Research. 97 (1–2): 32–8. doi:10.1159/000064052. PMID 12438735. S2CID 8347100.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126733 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025592 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Multiple transcript variants encoding different isoforms have been found for this gene. "Entrez Gene: Dachshund homolog 2 (Drosophila)". Retrieved 2012-04-15.

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DACH2

Function

References

Further reading

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