DGKQ
Protein-coding gene in the species Homo sapiens
Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene .[ 5] [ 6] [ 7]
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[ 7]
Interactions
DGKQ has been shown to interact with RHOA .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000145214 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004815 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics . 33 (1): 145–6. doi :10.1006/geno.1996.0174 . PMID 8617502 . ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain" . J Biol Chem . 272 (16): 10422–8. doi :10.1074/jbc.272.16.10422 PMID 9099683 . ^ a b "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa" .^ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA" . J. Biol. Chem . 274 (11): 6820–2. doi :10.1074/jbc.274.11.6820 ISSN 0021-9258 . PMID 10066731 .
Further reading
Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol . 29 (10): 1139–43. doi :10.1016/S1357-2725(97)00037-X . PMID 9438377 . Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17" . Mol. Cell. Biol . 27 (19): 6669–85. doi :10.1128/MCB.00355-07 . PMC 2099220 PMID 17664281 . van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C" . J. Biol. Chem . 280 (11): 9870–8. doi :10.1074/jbc.M409301200 PMID 15632189 . Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res . 287 (1): 143–54. doi :10.1016/S0014-4827(03)00115-0 . PMID 12799190 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA" . J. Biol. Chem . 274 (11): 6820–2. doi :10.1074/jbc.274.11.6820 PMID 10066731 . Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases" . J. Biol. Chem . 271 (14): 8394–401. doi :10.1074/jbc.271.14.8394 PMID 8626538 .
