DOC2A

DOC2A
Identifiers
AliasesDOC2A, Doc2, double C2 domain alpha
External IDsOMIM: 604567; MGI: 109446; GeneCards: DOC2A
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

8448

13446

Ensembl

ENSG00000149927

ENSMUSG00000052301

UniProt

Q14183

Q7TNF0

RefSeq (mRNA)

NM_001282062
NM_001282063
NM_001282068
NM_003586

NM_010069
NM_001368355
NM_001368356
NM_001368357
NM_001368358

RefSeq (protein)

NP_001268991
NP_001268992
NP_001268997
NP_003577

NP_034199
NP_001355284
NP_001355285
NP_001355286
NP_001355287

Location (UCSC)Chr 16: 30.01 – 30.02 MbChr 7: 126.45 – 126.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.[5][6][7]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca2+-dependent neurotransmitter release.[7]

Interactions

DOC2A has been shown to interact with UNC13B[6][8] and UNC13A.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149927 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052301 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
  6. ^ a b Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. Bibcode:1998PNAS...9511418M. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
  7. ^ a b "Entrez Gene: DOC2A double C2-like domains, alpha".
  8. ^ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
  9. ^ "Protein unc-13 homolog A". UniProt.

Further reading


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