Danielle Benoit

Danielle Benoit
Born
Danielle S. W. Benoit
EducationUniversity of Colorado Boulder (PhD, MS)
University of Maine (BS)
Known forResearch in biomaterials, drug delivery, and regenerative medicine
AwardsNational Science Foundation CAREER Award
Fellow of the National Academy of Inventors
Fellow of the Biomedical Engineering Society
Scientific career
FieldsBioengineering, biomaterials, tissue engineering
InstitutionsUniversity of Oregon
University of Rochester

Danielle S.W. Benoit is an American bioengineer and academic administrator. She is the Inaugural Chair of the Department of Bioengineering and the Lorry Lokey Chair at the University of Oregon's Knight Campus for Accelerating Scientific Impact. Her research focuses on the design of biomaterials for controlled drug delivery and regenerative medicine, specifically targeting bone tissue engineering and dental applications.

Education

Benoit earned a B.S. in biological engineering from the University of Maine in 2002.[1] She received an M.S. in chemical engineering in 2005 and a Ph.D. in chemical engineering in 2006 from the University of Colorado Boulder.[2]

Career

Benoit joined the University of Rochester in 2010 as a faculty member in biomedical engineering. Her appointments there included positions in biomedical engineering, chemical engineering, orthopaedics, the Center for Musculoskeletal Research,[3] biomedical genetics, and the Center for Oral Biology.[4] She later became William R. Kenan, Jr. Professor of Biomedical Engineering[5] and director of the university's Materials Science Program.[6]

In 2022, Benoit joined the University of Oregon as the inaugural chair of the Department of Bioengineering at the Knight Campus for Accelerating Scientific Impact.[7][8] She was also appointed Lorry Lokey Chair and professor of bioengineering.[9] In the same year, she was named a visiting professor at the University of Rochester.[10]

In 2025, she received the University of Oregon Office of the Provost Outstanding Department Head Award.[11]

Research

Benoit's research is centered on therapeutic biomaterials: engineered materials designed to interact with cells, tissues, and biological environments for applications in drug delivery and regenerative medicine. Her work has emphasized polymeric systems, including hydrogels and nanoparticles, that can deliver therapeutic agents locally, respond to biological conditions, or guide cell behavior.[12]

A major area of Benoit's research concerns biomaterials for bone regeneration and bone-targeted drug delivery. Her group has studied tissue engineering strategies for bone allograft repair, including engineered periosteum approaches and hydrogels designed to support vascularization, mineralization, and integration of grafts.[13] Her NSF CAREER Award project focused on polymer therapeutics for bone regeneration and on targeted drug-delivery systems for osteoporosis.[14] Later work from her group examined bone-targeted nanoparticle systems for modulating macrophage behavior during fracture healing.[15]

Another focus of her work is the development of responsive and targeted nanoparticle systems. Benoit's laboratory has studied pH-responsive nanoparticles for delivery of nucleic acids and small molecules, as well as surface-modified nanoparticles intended to alter protein adsorption and immune interactions in vivo.[16][17]

Benoit has also contributed to biomaterials research for tendon healing. In 2024, Benoit and collaborators reported a nanoparticle-based tendon-targeting drug-delivery system designed to pharmacologically modulate tendon healing.[18] Related work has examined anisotropic hydrogel systems intended to mimic aspects of the native tendon environment.[19]

Her research has further included salivary gland regeneration, tissue-chip systems, oral biofilm treatments, and microphysiological disease models. Benoit and collaborators have used salivary gland tissue-chip platforms for screening candidate radioprotective drugs.[20] Her group has also worked on nanoparticle-based approaches to oral biofilm treatments and anti-caries therapies.[21]

Awards and honors

References

  1. ^ a b "Professor Benoit receives University of Maine Francis Crowe Engineering Distinguished Alumni Award". University of Rochester.
  2. ^ "Alum Danielle Benoit Selected as 2015 Young Innovator by the Cellular and Molecular Bioengineering Journal | Chemical and Biological Engineering". University of Colorado Boulder.
  3. ^ "Research Labs - Center for Musculoskeletal Research - URochester Medicine". Rochester.edu.
  4. ^ ""Bubbles" Boost Search for Treatment to Aid Head and Neck Cancer Patients". University of Rochester Medicine.
  5. ^ Roach, Jennifer (19 July 2022). "Rochester faculty newly appointed to named professorships". University of Rochester.
  6. ^ "Researchers seek 'direct hit' on leukemic stem cells". Association of American Universities (AAU). 1 April 2022.
  7. ^ "First Bioengineering Chair Danielle Benoit". University of Oregon.
  8. ^ "Distinguished biomedical engineer to lead Knight Campus academic department | UO Knight Campus". Uoregon.edu.
  9. ^ "Meet Danielle Benoit UO's inaugural Bioengineering Chair". University of Oregon.
  10. ^ "Danielle Benoit". Rochester.edu.
  11. ^ "Outstanding Department Head Award". Office of the Provost. University of Oregon.
  12. ^ "Profile: Emerging Investigators 2016: novel design strategies for new functional materials". Journal of Materials Chemistry B. 2016. doi:10.1039/C6TB90055K.
  13. ^ March, A.; Hebner, T.; Choe, R.; Benoit, D. S. W. (2025). "Leveraging the predictive power of a 3D in vitro vascularization screening assay for hydrogel-based tissue-engineered periosteum allograft healing". Biomaterials Advances. 169: 214187.
  14. ^ "Benoit aims to develop a drug delivery system to treat Osteoporosis through NSF CAREER Award". Department of Biomedical Engineering. University of Rochester. 8 April 2016. Retrieved 15 May 2026.
  15. ^ Xiao, Baixue; Liu, Yuxuan; Chandrasiri, Indika; Adjei-Sowah, Emmanuela; Mereness, Jared; Yan, Min; Benoit, Danielle S. W. (2024). "Bone-targeted nanoparticle drug delivery system-mediated macrophage modulation for enhanced fracture healing". Small. 20 (7) e2305336. doi:10.1002/smll.202305336.
  16. ^ "Benoit Lab". UO Knight Campus.
  17. ^ Overby, Clyde; Park, Soomin; Summers, Austin; Benoit, Danielle S. W. (2023). "Zwitterionic peptides: Tunable next-generation stealth nanoparticle modifications". Bioactive Materials. 27: 113–124. doi:10.1016/j.bioactmat.2023.03.020.
  18. ^ Adjei-Sowah, Emmanuela; Chandrasiri, Indika; Xiao, Baixue; Liu, Yuxuan; Ackerman, Jessica E.; Soto, Celia; Nichols, Anne E. C.; Nolan, Katherine; Benoit, Danielle S. W.; Loiselle, Alayna E. (2024). "Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing". Science Advances. 10 (25) eadn2332. doi:10.1126/sciadv.adn2332. PMC 11186494.
  19. ^ Hebner, Tayler S.; Genc, Destina E.; Benoit, Danielle S. W. (16 February 2026). "Recapitulating the Native Tendon Environment in a Synthetic 3D Anisotropic Hydrogel as an Engineered Extracellular Matrix". ACS Applied Bio Materials. 9 (4): 2282–2293. doi:10.1021/acsabm.5c02408.
  20. ^ Piraino, Lindsay R.; Chen, Chiao Yun; Mereness, Jared A.; Dunman, Paul M.; Ovitt, Catherine E.; Benoit, Danielle S. W.; DeLouise, Lisa A. (2025). "Salivary gland tissue chip screening identifies candidate radioprotective drugs". Communications Medicine. 5 (1): 420. doi:10.1038/s43856-025-01136-7. PMC 12511423.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  21. ^ Benoit, Danielle S. W.; Sims, Kenneth R.; Fraser, David (28 May 2019). "Nanoparticles for Oral Biofilm Treatments". ACS Nano. 13 (5): 4869–4875. doi:10.1021/acsnano.9b02816. ISSN 1936-086X.
  22. ^ Sierra, Leonor (25 March 2015). "Three Rochester scientists receive prestigious NSF CAREER awards". University of Rochester.
  23. ^ "Profile: Emerging Investigators 2016: novel design strategies for new functional materials". Journal of Materials Chemistry B. 2016. pp. 2995–2998. doi:10.1039/C6TB90055K.
  24. ^ "Danielle Benoit is Rochester's "Young Engineer of the Year"". Rochester.edu.
  25. ^ "Acta Biomaterialia Outstanding Reviewers in 2017". ScienceDirect.com.
  26. ^ Marcotte, Bob (5 April 2019). "'Embodies the spirit' of teaching and mentorship". University of Rochester.
  27. ^ "Danielle Benoit, Ph.D. COF-4007". AIMBE.
  28. ^ "List of Fellows". BMES.
  29. ^ "CLASS OF 2023 FELLOWS" (PDF). National Academy of Inventors.
  30. ^ "Outstanding Department Head Award". University of Oregon.
  31. ^ "Acta Biomaterialia Silver Medal". Acta Materialia Inc.

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