He was elected as a member of the Senegalese Parliament from 1963 to 1970.[3] He became Senegal's Minister of Health under Prime Minister Abdou Diouf in 1970, a position he held until 1972.[3] He next served as Minister of Communications and Relations with Parliament, as well as a spokesperson for the government, from 1973 to 1980.[3]
Sow was elected the President of the National Assembly of Senegal on April 12, 1984, succeeding Habib Thiam.[3] He was re-elected in April 1988.[3] He was forced to resign as President of the Assembly on December 9, 1988, and was succeeded by Abdoul Aziz Ndaw.[3]
Sow remained a member of the PS until his death.[2] He also worked as the PS coordinator for Linguère Department.[2]